PREDICTING THE RISK OF DEVELOPING ABDOMINAL ADHESIONS IN CHILDREN DEPENDING ON ACETYLATION GENOTYPE

Objective. To determine the predictive value of genetic polymorphism N-arylacetyltransferase-2 (NAT-2) gene for assessing risk postoperative adhesive intestinal obstruction in children. Methods. In all children (36 with (main group) and 35 planned patients (comparative group)) acetylation genotype was studied by detecting point mutations NAT-2 using allele-specific amplification method analysis apolymerase chain reaction-restrictionfragmentlengthpolymorphism. Results. The study frequency at position 481 revealed greatest diversity variants genotypes: 33.3% main group were homozygous wild-type gene, 44.4% heterozygotes, 22.2% had a mutant gene. According to * 6A (G 590 - A), majority (55.6%) homozygotes Not single case mutation 857 has been identified. Among group, share «fast» acetylators 69.4%, comparison 40.0% (χ<sup>2</sup>=6.215; p=0.013). development “fast” occurred absence clinical anamnestic factors characterized greater severity prevalence intra-abdominal process (PAI (14.8±1.8) (8.1±2.4 ), respectively). Conclusion. developing complications can be done preventively determining N-acetyltransferase-2 is made up who are carriers alleles correspond «moderate» acetylation. Children have more pronounced adhesion higher associated excessive even other factors. What this paper adds N-acetyltransferase 2 (NAT2) as prognostic factor studied. acetylator adhesions therefore require comprehensive preventive measures stages possible influence.