Predicting False Discovery Proportion Under Dependence
نویسندگان
چکیده
منابع مشابه
Predicting False Discovery Proportion Under Dependence
We present a flexible framework for predicting error measures in multiple testing situations under dependence. Our approach is based on modeling the distribution of the probit transform of the p-values by mixtures of multivariate skew-normal distributions. The model can incorporate dependence among p-values and it allows for shape restrictions on the p-value density. A nonparametric Bayesian sc...
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MOTIVATION Wide-scale correlations between genes are commonly observed in gene expression data, due to both biological and technical reasons. These correlations increase the variability of the standard estimate of the false discovery rate (FDR). We highlight the false discovery proportion (FDP, instead of the FDR) as the suitable quantity for assessing differential expression in microarray data...
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The false discovery proportion (FDP) is a useful measure of abundance of false positives when a large number of hypotheses are being tested simultaneously. Methods for controlling the expected value of the FDP, namely the false discovery rate (FDR), have become widely used. It is highly desired to have an accurate prediction interval for the FDP in such applications. Some degree of dependence a...
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Multiple hypothesis testing is a fundamental problem in high dimensional inference, with wide applications in many scientific fields. In genome-wide association studies, tens of thousands of tests are performed simultaneously to find if any SNPs are associated with some traits and those tests are correlated. When test statistics are correlated, false discovery control becomes very challenging u...
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Multiple hypothesis testing is a fundamental problem in high dimensional inference, with wide applications in many scientific fields. In genome-wide association studies, tens of thousands of hypotheses are tested simultaneously to find if any genes are associated with some traits; in finance, thousands of tests are performed to see which fund managers have winning ability. In practice, these te...
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ژورنال
عنوان ژورنال: Journal of the American Statistical Association
سال: 2011
ISSN: 0162-1459,1537-274X
DOI: 10.1198/jasa.2011.tm10488