Predicting disease genes using protein-protein interactions
نویسندگان
چکیده
منابع مشابه
Predicting disease genes using protein-protein interactions.
BACKGROUND The responsible genes have not yet been identified for many genetically mapped disease loci. Physically interacting proteins tend to be involved in the same cellular process, and mutations in their genes may lead to similar disease phenotypes. OBJECTIVE To investigate whether protein-protein interactions can predict genes for genetically heterogeneous diseases. METHODS 72,940 pro...
متن کاملLETTER TO JMG Predicting disease genes using protein–protein interactions
Background: The responsible genes have not yet been identified for many genetically mapped disease loci. Physically interacting proteins tend to be involved in the same cellular process, and mutations in their genes may lead to similar disease phenotypes. Objective: To investigate whether protein–protein interactions can predict genes for genetically heterogeneous diseases. Methods: 72 940 prot...
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MOTIVATION Proteome-wide prediction of protein-protein interaction is a difficult and important problem in biology. Although there have been recent advances in both experimental and computational methods for predicting protein-protein interactions, we are only beginning to see a confluence of these techniques. In this paper, we describe a very general, high-throughput method for predicting prot...
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Motivation: Proteins play a fundamental role in every process within the cell. Understanding how proteins interact, and the functional units they are part of, is important to furthering our knowledge of the entire biological process. There has been a growing amount of work, both experimetal and computational, on determining the protein-protein interaction network. Recently researchers have had ...
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In this study, a high accuracy protein-protein interaction prediction method is developed. The importance of the proposed method is that it only uses sequence information of proteins while predicting interaction. The method extracts phylogenetic profiles of proteins by using their sequence information. Combining the phylogenetic profiles of two proteins by checking existence of homologs in diff...
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ژورنال
عنوان ژورنال: Journal of Medical Genetics
سال: 2006
ISSN: 1468-6244
DOI: 10.1136/jmg.2006.041376