منابع مشابه
Fate of MHC-matched corneal allografts in Th1-deficient hosts.
PURPOSE To determine whether the Th1 cytokine, interferon (IFN)-gamma, is necessary for corneal graft rejection. METHODS Full-thickness penetrating keratoplasties were performed in normal mice and in IFN-gamma knockout (KO) mice. RESULTS Sixty-four percent of the MHC-mismatched corneal allografts were rejected in IFN-gamma KO mice. By contrast, MHC-matched corneal allografts were rejected i...
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Based on the Randic suggestion of the resolution of a structure into shape, size, and function an index representing structure-catabolic fate relationships of amino acids is constructed. The index obtained by multiplying three factors; (nb2 + nr), nc and M; representing shape, size and function respectively, where nb2 = number of double bonds, nr = number of rings, nc = number of carbon atoms, ...
متن کاملFate of orthotopic corneal allografts in eyes that cannot support anterior chamber-associated immune deviation induction.
PURPOSE Corneal allografts placed in human eyes at high risk often fail, and immune rejection is thought to be a major pathogenic factor. To understand the immunologic factors responsible for rejection in this instance, the authors have created "high-risk" eyes in mice by inducing corneal neovascularization. The authors then examined the fate of orthotopic corneal grafts placed in these beds an...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2011
ISSN: 0085-2538
DOI: 10.1038/ki.2011.328