منابع مشابه
Diurnal variation of cholesterol precursors squalene and methyl sterols in human plasma lipoproteins.
Animal cholesterol synthesis shows a marked diurnal variation, a phenomenon, at the moment, not known to occur in man. Since cholesterol precursors in serum reflect overall cholesterol synthesis in many conditions, a 24-hr profile of squalene and methyl sterols was studied in plasma lipoproteins in order to demonstrate whether these cholesterol precursors could exhibit a diurnal cycling in heal...
متن کاملSqualene-2,3oxide, an intermediate in the enzymatic conversion of squalene to lanosterol and cholesterol.
The conversion of squalene to lanosterol by rat liver preparations in vitro has been re-examined. It has been shown that this transformation, hitherto considered to take place through the agency of one enzyme (“squalene oxidocyclase-1”), actually involves the formation of squalene-2,3oxide as an intermediate. The oxide is cyclized to lanosterol by a cyclizing system which acts independently of ...
متن کاملCholesterol precursors and facial clefting.
Inborn errors of cholesterol synthesis cause human malformation syndromes, including Smith-Lemli-Opitz syndrome, lathosterolosis, desmosterolosis, X-linked dominant chondrodysplasia punctata type 2, and congenital hemidysplasia with ichthyosiform erythroderma and limb defects. Because adequate cholesterol is not transported across the placenta, low cholesterol and elevated sterol precursor leve...
متن کاملStudies of sebum. VIII. Observations on the squalene and cholesterol content and the possible functions of squalene in human sebum.
The object of our investigations has been to study the composition ofsebum and to elucidate its role in maintaining the health of the skin. In a previous paper on the hydrocarbons of sebum (Boughton, Hodgson-Jones, MacKenna, Wheatley & Wormall, 1955) we observed that the squalene content of sebum showed wide variations, both in samples collected from the same subject on different occasions and ...
متن کاملSqualene as a precursor of cholesterol in liver.
Many compounds have been implicated as capable of serving as precursors for cholesterol, and of these the most intriguing is undoubtedly squalene. In 1926, and again in 1937, Channon (1, 2) reported that the .feeding of squalene to rats resulted in an increased cholesterol content of the liver. These observations led Srere (3), in 1949, in this laboratory, to study the conversion of acetate-Cl4...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1957
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)63688-4