Preclinical xenograft models of human sarcoma show nonrandom loss of aberrations
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چکیده
منابع مشابه
Antibodies targeting human IL1RAP (IL1R3) show therapeutic effects in xenograft models of acute myeloid leukemia.
Acute myeloid leukemia (AML) is associated with a poor survival rate, and there is an urgent need for novel and more efficient therapies, ideally targeting AML stem cells that are essential for maintaining the disease. The interleukin 1 receptor accessory protein (IL1RAP; IL1R3) is expressed on candidate leukemic stem cells in the majority of AML patients, but not on normal hematopoietic stem c...
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ژورنال
عنوان ژورنال: Cancer
سال: 2011
ISSN: 0008-543X
DOI: 10.1002/cncr.26276