Precision Oncology: Between Vaguely Right and Precisely Wrong

Actionability and precision oncology.

Cancer is driven by molecular aberrations that allow oncogenic cells to thrive by growing and eventually metastasizing, and/or by alterations in the tumor or host that are permissive for immune evasion. The development and availability of clinical-grade molecular diagnostic tests that interrogate the genomic portfolio of each patient's tumor, together with the clinical development of a myriad o...

Right pace, wrong place.

Right cell, wrong cell.

Left is right, right is wrong.

correspondence correspondence Left is right, right is wrong T he cover illustration of the August 2009 issue of EMBO reports, although aesthetically pleasing, is unfortunately erroneous and could come as a shock to researchers in the chromatin field. Canonical nucleosomes are indeed left-handed, such as the nucleosomes in the left 'column' of chro-matin fibres on the cover. However, in the righ...

Precision oncology: an overview.

In this Special Series issue, Journal of Clinical Oncology presents a systematic assessment of cancer genomic information and its accelerating clinical impact. In the scientific literature and lay press, the relevant discipline is often called personalized, or precision, cancer medicine. The word personalized conveys the sense that cancer genomic data may facilitate rational treatment choices t...