Precision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness

Precision medicine for all? Challenges and opportunities for a precision medicine approach to critical illness

All of medicine aspires to be precise, where a greater understanding of individual data will lead to personalized treatment and improved outcomes. Prompted by specific examples in oncology, the field of critical care may be tempted to envision that complex, acute syndromes could bend to a similar reductionist philosophy-where single mutations could identify and target our critically ill patient...

94inimmunotherapy for Cancer: New Challenges and Opportunities for Precision Medicine.

Immunotherapy of cancer is presently one of the areas where major medical breakthroughs are witnessed, with dazzling results reported by several groups recently. Two approaches stand out: On one hand, neutralizing antibodies that disable key inhibitory receptors regulating T lymphocyte function, such as CTLA-4 and PD-1, enable the potent activation of effector T cells against tumors. On the oth...

Disease Biomarkers for Precision Medicine: Challenges and Future Opportunities

Center for Health Genomics and Informatics, University of Calgary Cumming School of Medicine, Calgary, AB T2N 4N1, Canada Department of Clinical Oncology, Queen Elizabeth Hospital, Hong Kong Special Administrative Region Department of Health Technology and Informatics, Faculty of Health and Social Sciences, Hong Kong Polytechnic University, Hong Kong Special Administrative Region CAS Key Labora...

Clinical tumor sequencing: opportunities and challenges for precision cancer medicine.

Advances in tumor genome sequencing have enabled discovery of actionable alterations leading to novel therapies. Currently, there are approved targeted therapies across various tumors that can be matched to genomic alterations, such as point mutations, gene amplification, and translocations. Tools to detect these genomic alterations have emerged as a result of decreasing costs and improved thro...

precision medicine for endocrinology