Precise control of the site selectivity in ruthenium-catalyzed C–H bond amidations using cyclic amides as powerful directing groups
نویسندگان
چکیده
A ruthenium-catalyzed C–H amidation using cyclic amides as directing groups features broad functional group tolerance. Mechanistic studies supported by DFT calculations highlight the relevance of six-membered ruthenacycles in catalytic cycle.
منابع مشابه
Unexpected selectivity in ruthenium-catalyzed hydrosilylation of primary amides: synthesis of secondary amines.
Selective ruthenium-catalyzed reductive coupling of primary amides under hydrosilylation conditions is achieved using an one pot procedure. Using 3 equiv. of phenylsilane and [RuCl2(mesitylene)]2 (1-2 mol%) as the catalyst at 100 °C under neat conditions, secondary symmetric amines were obtained in good yields and with high chemoselectivities.
متن کاملInternal strain on the bond length and rate of hydrolysis in cyclic amides
The internal strain in cyclic amides are explained as a factor of resonance that are effected on the bond length C-N and are a major factor of rates of hydrolysis. The cyclic amides in this study are optimized by Gaussian program and the bond length of C-N in the rings are studied by HF/6-31G*.
متن کاملTheoretical study of the effect of internal strain on the bond length and rate of hydrolysis in cyclic amides
The internal strain in cyclic amides are explained as a factor of resonance that are effected on the bond length C-N and are a major factor of rates of hydrolysis. The cyclic amides in this study are optimized by Gaussian program and the bond length of C-N in the rings are studied by HF/6-31G*.
متن کاملTheoretical study of the effect of internal strain on the bond length and rate of hydrolysis in cyclic amides
The internal strain in cyclic amides are explained as a factor of resonance that are effected on the bond length C-N and are a major factor of rates of hydrolysis. The cyclic amides in this study are optimized by Gaussian program and the bond length of C-N in the rings are studied by HF/6-31G*.
متن کاملRuthenium-catalyzed annulation of alkynes with amides via formyl translocation.
The first example of Ru-catalyzed intramolecular annulation of alkynes with amides via formyl translocation has been developed, which provides an efficient approach for the synthesis of 1H-indole-3-carbaldehydes.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Organic chemistry frontiers
سال: 2023
ISSN: ['2052-4110', '2052-4129']
DOI: https://doi.org/10.1039/d2qo01434c