Precipitated Toxoid as an Immunizing Agent Against Diphtheria
نویسندگان
چکیده
منابع مشابه
The Purification and Concentration of Diphtheria Toxoid
By precipitation with acetone at 4 degrees C. a refined diphtheria toxoid was obtained as a dry powder, readily soluble in aqueous solutions. The powder itself appears to be stable. When dissolved in half the original volume of physiological salt solution, the toxoid remained stable, in the cold room, for a period of 7 months. Only toxoids should be used which have been completely detoxified by...
متن کاملThe Relation of Toxoid Dilution to Immunizing Capacity *
Thus far most of those procedures adopted for the production of antibody have been of an arbitrary nature with attention chiefly directed toward the quality and quantity of the antigen and the parenteral route of its introduction. It is, however, becoming more and more clear that the factors which govern the extent to which an animal of a given species will respond with elaboration of antibody ...
متن کاملPreparation and in-vitro evaluation of sodium alginate microspheres containing diphtheria toxoid as new vaccine delivery
During last two decades, polysaccharides such as alginate (Alg) alone and in combination with other biopolymers are widely used in vaccine and drug delivery systems. The aim of the present work was to investigate the potential utility of microparticles made of alginate (Alg) as new vehicles for improving nasal vaccine delivery. For this purpose, diphtheria toxoid (DT) was chosen as a model an...
متن کاملPreparation and Evaluation of Diphtheria Toxoid-Containing Microspheres
Preparation of chitosan (CS) microspheres as a novel drug delivery vehicle for intranasal immunization using high, medium and low CS molecular weight (MW) was investigated in this study. Diphtheria toxoid (DT) was used as a model antigen. The emulsion-solidification method was adopted for microencapsulation of DT. In the first step, following the purification of semi-crude DT by the ion-exchan...
متن کاملProtection against group A streptococcus by immunization with J8-diphtheria toxoid: contribution of J8- and diphtheria toxoid-specific antibodies to protection.
A conformationally constrained, minimally conserved peptide from the M protein of group A streptococcus (GAS) has been defined. It consists of 12 amino acids from the C-repeat region within a non-M protein helix-forming sequence and is referred to as "J8." Here, we investigate the immunogenicity of a J8-diphtheria toxoid (DT) conjugate adjuvanted with the human-compatible adjuvants, SBAS2 and a...
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ژورنال
عنوان ژورنال: American Journal of Public Health and the Nations Health
سال: 1934
ISSN: 0002-9572
DOI: 10.2105/ajph.24.1.22