Pre- and Post-Ischemic Administration of Dizocilpine (MK-801) Reduces Cerebral Necrosis in the Rat
نویسندگان
چکیده
منابع مشابه
Pre-Ischemic Treatment of Pentoxifylline Reduces Infarct Volumes in Transient Focal Cerebral Ischemia in the Rat
Background: Pentoxifylline (PTX) is used in human for intermittent claudication and cerebral vascular disorders including cerebrovascular dementia. It also inhibits the synthesis of tumor necrosis factor-α (TNF-α), which is believed to be neurotoxic in animal models of cerebral ischemia. The objective of this study was to examine the role of PTX on ischemia/reperfusion injures in rat model of t...
متن کاملThe effects of MK-801 and U-83836E on post-ischemic reperfusion injury in rat brain.
Rats were subjected to incomplete cerebral ischemia induced by occlusion of common carotid arteries for 30 min, and subsequent reperfusion for 15 min. The concentrations of reduced glutathione (GSH), malondialdehyde (MDA) and superoxide dismutase (SOD) activity were determined in the dorsal hippocampus in order to evaluate their changes during ischemia and reperfusion following ischemia. The de...
متن کاملClinical physiology and mechanism of dizocilpine (MK-801)
Dizocilpine (MK-801), an extensively investigated drug possessing secondary amine and benzenoid functions, displays a wide array of biological properties, including anticonvulsant and anesthetic. There is scant discussion of biomechanism. A relevant, important finding is formation of oxidative metabolites in the hydroxylamine and phenolic categories. Analogy to cocaine metabolites suggests part...
متن کاملProtective effect of dizocilpine (MK-801) on TNBS-induced experimental colitis in mice
Ulcerative colitis is chronic and recurrent disease of the gastrointestinal tract with uncertain etiology and incomplete treatment options. N-methyl-d-aspartate (NMDA) receptor suppression has shown anti-inflammatory effects in vitro and in vivo. The aim of present study was to evaluate the role of dizocilpine (MK-801), a noncompetitive NMDA receptor antagonist, on TNBS (trinitrobenzene sulfoni...
متن کاملpre-ischemic treatment of pentoxifylline reduces infarct volumes in transient focal cerebral ischemia in the rat
background: pentoxifylline (ptx) is used in human for intermittent claudication and cerebral vascular disorders including cerebrovascular dementia. it also inhibits the synthesis of tumor necrosis factor-α (tnf-α), which is believed to be neurotoxic in animal models of cerebral ischemia. the objective of this study was to examine the role of ptx on ischemia/reperfusion injures in rat model of t...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques
سال: 1989
ISSN: 0317-1671,2057-0155
DOI: 10.1017/s031716710002919x