PRE-084, a σ selective PCP derivative, attenuates MK-801-induced impairment of learning in mice
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منابع مشابه
Protective effect of dizocilpine (MK-801) on TNBS-induced experimental colitis in mice
Ulcerative colitis is chronic and recurrent disease of the gastrointestinal tract with uncertain etiology and incomplete treatment options. N-methyl-d-aspartate (NMDA) receptor suppression has shown anti-inflammatory effects in vitro and in vivo. The aim of present study was to evaluate the role of dizocilpine (MK-801), a noncompetitive NMDA receptor antagonist, on TNBS (trinitrobenzene sulfoni...
متن کاملProtective effect of dizocilpine (MK-801) on TNBS-induced experimental colitis in mice
Ulcerative colitis is chronic and recurrent disease of the gastrointestinal tract with uncertain etiology and incomplete treatment options. N-methyl-d-aspartate (NMDA) receptor suppression has shown anti-inflammatory effects in vitro and in vivo. The aim of present study was to evaluate the role of dizocilpine (MK-801), a noncompetitive NMDA receptor antagonist, on TNBS (trinitrobenzene sulfoni...
متن کاملDifferential Effects of Olanzapine and Haloperidol on MK-801-induced Memory Impairment in Mice
OBJECTIVE We investigated the differential effects of the antipsychotic drugs olanzapine and haloperidol on MK-801-induced memory impairment and neurogenesis in mice. METHODS MK-801 (0.1 mg/kg) was administered 20 minutes prior to behavioral testing over 9 days. Beginning on the sixth day of MK-801 treatment, either olanzapine (0.05 mg/kg) or haloperidol (0.05 mg/kg) was administered 40 minut...
متن کاملPharmacological or genetic orexin1 receptor inhibition attenuates MK-801 induced glutamate release in mouse cortex
The orexin/hypocretin neuropeptides are produced by a cluster of neurons within the lateral posterior hypothalamus and participate in neuronal regulation by activating their receptors (OX1 and OX2 receptors). The orexin system projects widely through the brain and functions as an interface between multiple regulatory systems including wakefulness, energy balance, stress, reward, and emotion. Re...
متن کاملBDNF Pretreatment Attenuates Morphine-Induced Learning and Memory Impairment in Rats
Background: It has been known that Brain-Derived Neurotrophic Factor (BDNF) is involved in neural survival and long term memory (LTM). Here we hypothesized that BDNF as a potent neurotrophic factor might modulate amnestic effect induced by morphine. Objectives: The aim of this study was to examine whether infusion of exogenous BDNF in the CA1 regions of the dorsal hippocampi could ameliorate me...
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ژورنال
عنوان ژورنال: Pharmacology Biochemistry and Behavior
سال: 1994
ISSN: 0091-3057
DOI: 10.1016/0091-3057(94)90235-6