‘Pragmatic’ and ‘explanatory’ attitudes to randomised trials
نویسندگان
چکیده
منابع مشابه
'Pragmatic' and 'explanatory' attitudes to randomised trials.
In the early days of randomised control trials the ability to reduce confounding fromknownand unknown confounders rightly underpinned their rapid rise in methodological popularity. Ever since, however, concerns have been expressed by the clinician community and others about the difficulty of applying estimates of effects derived from randomised control trials to settings and patient populations...
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It is the thesis of this paper that most therapeutic trials are inadequately formulated, and this from the earliest stages of their conception. Their inadequacy is basic, in that the trials may be aimed at the solution of one or other of two radically different kinds of problem; the resulting ambiguity affects the definition of the treatments, the assessment of the results, the choice of subjec...
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Randomised controlled trials are the best research design for decisions about the effect of different interventions but randomisation does not, of itself, promote the applicability of a trial's results to situations other than the precise one in which the trial was done. While methodologists and trialists have rightly paid great attention to internal validity, much less has been given to applic...
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In the pragmatic-explanatory continuum, a randomized controlled trial (RCT) can at one extreme investigate whether a treatment could work in ideal circumstances (explanatory), or at the other extreme, whether it would work in everyday practice (pragmatic). How explanatory or pragmatic a study is can have implications for clinicians, policy makers, patients, researchers, funding bodies, and the ...
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ژورنال
عنوان ژورنال: Journal of the Royal Society of Medicine
سال: 2017
ISSN: 0141-0768,1758-1095
DOI: 10.1177/0141076817706303