Practical Methods for Molecular In Vivo Optical Imaging

Computational methods for optical molecular imaging.

A new computational technique, the matched interface and boundary (MIB) method, is presented to model the photon propagation in biological tissue for the optical molecular imaging. Optical properties have significant differences in different organs of small animals, resulting in discontinuous coefficients in the diffusion equation model. Complex organ shape of small animal induces singularities...

Practical Considerations for in Vivo THz Imaging

Terahertz imaging systems have advanced significantly over recent years and now in vivo terahertz imaging is plausible. In this paper we discuss the constraints that need to be considered in designing and implementing a terahertz system for in vivo imaging. We describe the requirements and limitations of system geometry, data acquisition rate, image resolution and penetration depth. Furthermore...

In Vivo Optical Imaging

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In vivo magnetomotive optical molecular imaging using targeted magnetic nanoprobes.

Dynamic magnetomotion of magnetic nanoparticles (MNPs) detected with magnetomotive optical coherence tomography (MM-OCT) represents a new methodology for contrast enhancement and therapeutic interventions in molecular imaging. In this study, we demonstrate in vivo imaging of dynamic functionalized iron oxide MNPs using MM-OCT in a preclinical mammary tumor model. Using targeted MNPs, in vivo MM...

Analysis Methods for Optical Imaging