Practical Applications of Chromosomal Microarray in Prenatal Diagnosis

Abstract G-banded karyotyping is the most common approach for detection of genomic alterations. However, this unable to detect changes less than 5 Mb. The ability fluorescence in situ hybridization (FISH) cryptic chromosomal rearrangements exceeds resolution routine karyotype. conventional FISH targeted regions only, whereas microarray a whole-genome copy number evaluation technique with 10 20 kb. In article, we discuss application 750 K 384 consecutive prenatal diagnosis cases. Overall diagnostic yield 15.36%, and accounts 3.6% additional rate. We suggest applying as first-tier test along backup culture all