PPARδ attenuates hepatic steatosis through autophagy-mediated fatty acid oxidation
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چکیده
منابع مشابه
TFE3 Alleviates Hepatic Steatosis through Autophagy-Induced Lipophagy and PGC1α-Mediated Fatty Acid β-Oxidation.
Autophagy flux deficiency is closely related to the development of hepatic steatosis. Transcription factor E3 (TFE3) is reported to be a crucial gene that regulates autophagy flux and lysosome function. Therefore, we investigated the role of TFE3 in a cell model of hepatic steatosis. We constructed L02 hepatocyte lines that stably over-expressed or knocked down the expression of TFE3. Subsequen...
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Word count (including the Abstract): 3843 Keywords: Amiodarone Drug Drug-induced liver disease Fatty acid oxidation Fatty liver Membrane potential Mitochondria Nucleoside reverse transcriptase inhibitors Obesity Oxidative phosphorylation Oxidative stress Reactive oxygen species Respiratory chain Steatosis Tamoxifen Tetracycline Triglycerides Valproic acid Abstract Drug-induced inhibition of mit...
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ژورنال
عنوان ژورنال: Cell Death & Disease
سال: 2019
ISSN: 2041-4889
DOI: 10.1038/s41419-019-1458-8