PPAR-γ: A Thrifty Transcription Factor

PPAR-γ: a thrifty transcription factor

The peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a prototypical metabolic nuclear receptor that acts as a lipid sensor, integrating the homeostatic control of energy, lipid, and glucose metabolism. This perspective will highlight three lines of evidence which place PPAR-gamma as a key player in a feed-forward pathway favoring differentiation and energy storage by adipocytes.

PPAR-γ: Therapeutic Potential for Multiple Sclerosis

The role of peroxisome proliferator-activated receptors (PPARs) in altering lipid and glucose metabolism is well established. More recent studies indicate that PPARs also play critical roles in controlling immune responses. We and others have previously demonstrated that PPAR-gamma agonists modulate the development of experimental autoimmune encephalomyelitis (EAE), an animal model of multiple ...

PPAR-γ in the Cardiovascular System

Peroxisome proliferator-activated receptor-gamma (PPAR-gamma), an essential transcriptional mediator of adipogenesis, lipid metabolism, insulin sensitivity, and glucose homeostasis, is increasingly recognized as a key player in inflammatory cells and in cardiovascular diseases (CVD) such as hypertension, cardiac hypertrophy, congestive heart failure, and atherosclerosis. PPAR-gamma agonists, th...

metabolic syndrome and mitochondrial transcription factor a

A Thrifty Universal Construction

A universal construction is an algorithm which transforms any sequential implementation of an object into a concurrent implementation of that same object in a linearizable and wait-free manner. Such constructions require underlying low-level universal shared objects such as compare-and-swap and load-linked/store-conditional . In this paper, we present the first universal construction that (a) u...