PP120—Chemotherapeutic antitumor activities of curcumin
نویسندگان
چکیده
منابع مشابه
Anticancer Activities of Curcumin
Curcumin, an active constituent of Curcuma longa, is responsible for the for anticarcinogenic activities which is mediated through multiple mechanisms. Curcumin affects the major transcription factors such as nuclear factor k-light chain-enhancer of activated B cell(NF-kB) and activator protein-1 (AP-1).These factors regulate inflammation and are responsible for cell proliferation, differentiat...
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To evaluate the effects of curcumin (CUR) on tumor progression and angiogenesis in cervical cancer- (CaSki-) implanted nude mice and on the angiogenic biomarkers: vascular endothelial growth factor (VEGF), cyclooxygenase-2 (COX-2), and epidermal growth factor receptor (EGFR). CaSki cells were subcutaneously injected in nude mice to establish subcutaneous tumors. One month after injection, mice ...
متن کاملThe antitumor activities of flavonoids.
The flavonoids are polyphenolic compounds found as integral components of the human diet. They are universally present as constituents of flowering plants, particularly of food plants. The flavonoids are phenyl substituted chromones (benzopyran derivatives) consisting of a 15-carbon basic skeleton (C6-C3-C6), composed of a chroman (C6-C3) nucleus (the benzo ring A and the heterocyclic ring C), ...
متن کاملSynergistic antitumor efficiency of docetaxel and curcumin against lung cancer.
Curcumin (Cum), the principal polyphenolic curcuminoid, obtained from the turmeric rhizome Curcuma longa, is recently reported to have potential antitumor effects in vitro and in vivo. Docetaxel (Doc) is considered as first-line chemotherapy for the treatment of non-small cell lung cancer. Here we report for the first time that Cum could synergistically enhance the in vitro and in vivo antitumo...
متن کاملAntiangiogenic activities and cisplatin-combined antitumor activities of BPR0L075.
BACKGROUND Antimitotic tubulin-binding BPR0L075 is structurally analogous to the vascular-disrupting combretastatin A-4. MATERIALS AND METHODS In vitro/in vivo models of endothelial cells cultures, Matrigel plug assay, tumor-bearing nude mice, and murine leukemia cells-inoculated mice were utilized to evaluate BPR0L075 for antiangiogenic and antitumoral activity spectra. RESULTS BPR0L075 co...
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ژورنال
عنوان ژورنال: Clinical Therapeutics
سال: 2013
ISSN: 0149-2918
DOI: 10.1016/j.clinthera.2013.07.143