Poxvirus vectors: orphaned and underappreciated

Poxvirus vectors: orphaned and underappreciated.

Autogynephilia: an underappreciated paraphilia.

Autogynephilia is defined as a male's propensity to be sexually aroused by the thought of himself as a female. It is the paraphilia that is theorized to underlie transvestism and some forms of male-to-female (MtF) transsexualism. Autogynephilia encompasses sexual arousal with cross-dressing and cross-gender expression that does not involve women's clothing per se. The concept of autogynephilia ...

Quantifying Orphaned Annotations in Hypothes.is

Web annotation has been receiving increased attention recently with the organization of the Open Annotation Collaboration and new tools for open annotation, such as Hypothes.is. In this paper, we investigate the prevalence of orphaned annotations, where a live Web page no longer contains the text that had previously been annotated in the Hypothes.is annotation system (containing 6281 highlighte...

Macromolecular crowding: obvious but underappreciated.

Biological macromolecules evolve and function within intracellular environments that are crowded with other macromolecules. Crowding results in surprisingly large quantitative effects on both the rates and the equilibria of interactions involving macromolecules, but such interactions are commonly studied outside the cell in uncrowded buffers. The addition of high concentrations of natural and s...

Alcoholism and Catatonia: An Underappreciated Relationship

Catatonia is a complex neuropsychiatric syndrome that has been described in medical literature since the 16th century [1]. Lifethreatening complications involving every organ system can ensue, signaling high levels of associated morbidity and mortality [2]. To this day, little is known about the etiology of catatonia [3]. Catatonia occurs most frequently in patients with affective disorders and...