Powerful screens for bacterial virulence proteins
نویسندگان
چکیده
منابع مشابه
Powerful screens for bacterial virulence proteins.
M any mammalian and plant pathogenic bacteria inject virulence effector proteins into host cells by means of the type III secretion system (TTSS) (1). Effector proteins attack the host innate immune system, modify cytoskeleton and membranes, or alter vesicle trafficking (2, 3). The collective action of these proteins promotes bacterial entry into, growth and movement within, and dissemination f...
متن کاملBacterial moonlighting proteins and bacterial virulence.
Implicit in the central dogma is the hypothesis that each protein gene product has but one function. However, over the past decade, it has become clear that many proteins have one or more unique functions, over-and-above the principal biological action of the specific protein. This phenomenon is now known as protein moonlighting and many well-known proteins such as metabolic enzymes and molecul...
متن کاملMultitasking Bacterial Moonlighting Proteins in Bacterial Virulence and Infectious Disease
Men may not be able to multitask, but it seems that proteins can. Although the one gene-one protein-one function hypothesis is well ingrained in the Central Dogma, it has become clear during the past decade that many proteins have one or more unique functions in addition to their primary biological action. These proteins perform multiple independent and often unrelated roles without partitionin...
متن کاملType III effector proteins: doppelgangers of bacterial virulence.
Bacterial pathogens have co-evolved with their hosts in their ongoing quest for advantage in the resulting interaction. These intimate associations have resulted in remarkable adaptations of prokaryotic virulence proteins and their eukaryotic molecular targets. An important strategy used by microbial pathogens of animals to manipulate host cellular functions is structural mimicry of eukaryotic ...
متن کاملPowerful Drosophila screens that paved the wingless pathway
The Wnt/Wingless (Wg) signaling cascade controls a number of biological processes in animal development and adult life; aberrant Wnt/Wg signaling can cause diseases. In the 1980s genes were discovered that encode core Wnt/Wg pathway components: their mutant phenotypes were similar and an outline of a signaling cascade emerged. Over the years our knowledge of this important signaling system incr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 2005
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.0500724102