Potentiation of Isoniazid Efficacy against Isoniazid-resistant Mycobacteria Strains
نویسندگان
چکیده
منابع مشابه
In vitro anti-mycobacterial activity of (E)-N'-(monosubstituted-benzylidene) isonicotinohydrazide derivatives against isoniazid-resistant strains
A series of twenty-three N-acylhydrazones derived from isoniazid (INH 1-23) have been evaluated for their in vitro antibacterial activity against INH- susceptible strain of M. tuberculosis (RG500) and three INH-resistant clinical isolates (RG102, RG103 and RG113). In general, derivatives 4, 14, 15 and 16 (MIC=1.92, 1.96, 1.96 and 1.86 µM, respectively) showed relevant activities against RG500 s...
متن کاملTreatment of isoniazid-resistant pulmonary tuberculosis
BACKGROUND Although resistance to isoniazid (INH) is the most common form of drug resistance seen among Mycobacterium tuberculosis isolates, there have been few studies on the efficacy and optimal duration of treatment for patients with INH-resistant tuberculosis (TB). METHODS We evaluated retrospectively the treatment outcomes of 39 patients who were treated for INH-resistant pulmonary TB. T...
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Transduction of resistance to isoniazid and streptomycin as well as susceptibility to isoniazid in Mycobacterium smegmatis SN2 has been demonstrated. A method has been described for the selection of isoniazid-susceptible variants after transduction of susceptibility.
متن کاملRole of superoxide in catalase-peroxidase-mediated isoniazid action against mycobacteria.
Isoniazid (INH) activation in vitro is associated with reduction of the mycobacterial ferric KatG catalase-peroxidase by hydrazine and reaction with O2 to form an oxyferrous enzyme complex. Since this complex could also form directly via reaction of ferric KatG with superoxide, intracellular activation might be responsive to superoxide concentration. When Mycobacterium smegmatis carrying the M....
متن کاملPotentiation of Epileptogenic Effect of Isoniazid By Ethanol Consumption
The incidence of adverse reaction to isoniazid was estimated to be 3.4% in a study done in more than 3000 patients treated with this drug. The most common adverse effect being rash (2%), fever (1.2%), jaundice (0.6%) and peripheral neuritis (0.6%). If pyridoxine is not given concurrently, the incidence of peripheral neuritis (most commonly parasthesias of hands and feet) is the most common adve...
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ژورنال
عنوان ژورنال: Research Journal of Medicinal Plant
سال: 2014
ISSN: 1819-3455
DOI: 10.3923/rjmp.2014.32.40