Potential Role of Soluble ST2 Protein in Idiopathic Nephrotic Syndrome Recurrence Following Kidney Transplantation
نویسندگان
چکیده
منابع مشابه
Potential role of soluble ST2 protein in idiopathic nephrotic syndrome recurrence following kidney transplantation.
BACKGROUND Corticosteroid-resistant idiopathic nephrotic syndrome (INS) recurs rapidly after transplantation in 30% to 50% of transplant recipients, suggesting the presence of 1 or more circulating factors that alter the glomerular filtration barrier. We investigated the possible role in INS recurrence of soluble ST2 (sST2) protein, a marker of T helper type 2 (T(H)2) cells and a factor predict...
متن کاملHigh levels of soluble ST2 protein in recurrence of idiopathic nephrotic syndrome after kidney transplantation
After transplantation, corticosteroid-resistant Idiopathic Nephrotic Syndrome (INS) rapidly recurs in 30-50% of recipients, suggesting the presence of (a) circulating factor(s) which alter(s) the glomerular filtration barrier. In this paper, we investigated the possible implication of the soluble ST2 protein (sST2), a product of the c-maf pathway and a marker of Th2 cells, in the development of...
متن کاملComparison of Daily versus Every Other Day Treatment Regimen of Levamisole to Control Recurrence in the Childhood Idiopathic Nephrotic Syndrome
Background Idiopathic nephrotic syndrome is a kidney involvement that causes edema and heavy proteinuria with severe complications if the treatment is started late. The present study aimed to assess the efficacy of Levamisole in the daily versus every other day treatment regimen to control recurrence in Childhood Idiopathic Nephrotic Synd...
متن کاملDevelopment of initial idiopathic nephrotic syndrome and post-transplantation recurrence: evidence of the same biological entity.
BACKGROUND Buffalo/Mna rats spontaneously develop a nephrotic syndrome (NS). We have demonstrated that this rat nephropathy recurs after renal transplantation. We studied this recurrence by kinetic analysis of graft lesions, infiltrating cells and cytokines. METHODS Kidneys from LEW.1 W rats were grafted into proteinuric Buff/Mna or healthy Wistar Furth recipients. Kidney samples were harvest...
متن کاملAcute kidney injury in adult idiopathic nephrotic syndrome.
OBJECTIVE This study aims to investigate the epidemiology, clinical and histological features, and prognosis of acute kidney injury (AKI) according to RIFLE classification in adult patients with idiopathic nephrotic syndrome. METHODS In this retrospective study, 277 patients with idiopathic nephrotic syndrome were reviewed from June 2005 to June 2009. RESULTS Fifty-one (18%) patients entere...
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ژورنال
عنوان ژورنال: American Journal of Kidney Diseases
سال: 2009
ISSN: 0272-6386
DOI: 10.1053/j.ajkd.2009.03.021