Potential of Impatiens balsamina Leaf Extract against Quorum Sensing in Pseudomonas aeruginosa PA01

Bacteria control gene expression by quorum sensing (QS) mechanism owing to producing small signal molecules associated with population density. Both gram-positive and gram-negative bacteria use QS manage various physiological characteristics, including bioluminescence, virulence expression, biofilm formation, antibiotic resistance. Impatience balsamina is a flowering, perennial annual herb indigenous southern Asia in India. All parts of have therapeutic effect on different diseases. This study evaluated the anti-quorum activity leaf extract examining its action Violacein production Chromobacterium violaceum, biosensor strain, Biofilm, Pyocyanin, Protease, Chitinase reference strain Pseudomonas aeruginosa PA 01. Minimum inhibitory concentration (MIC) for 01was 3.125mg/ml. A 1.563mg/ml (sub-MIC) showed inhibition 100% Las protease, 78.42% chitinase, 30.75% biofilm, 93.33% pyocyanin article displayed quenching hindering quorum-sensing controlled characteristics without killing it, which reduces proneness drug resistance bacteria, globally accepted emerging problem medical field.