Potential Multiple Myeloma Therapeutic Strategies through Targeting Macrophages and Mesenchymal Stromal Cells

Multiple Myeloma (MM), a bone marrow plasma cell hematopoietic cancer, remains critical but incurable hematological malignancy, prone to deadly relapses even after existing treatment. In this review, I describe the origins of pro-tumor myeloma-associated macrophages. specifically outline how classically activated anti-tumor macrophages that home cancerous tumor microenvironment is polarized into We then explain these play an important role in supporting multiple myeloma by enabling drug resistance, improved growth, angiogenesis, and protection. also several treatments development aimed sever supportive link between MM blocking signaling pathways, destroying, or repolarizing preventing macrophage polarization first place. conclude careful study needed improve reliability targeting reduce relapse comprehensively treat cancer.