Potential apply of hydrogel-carried chlorhexidine and metronidazole in root canal disinfection
نویسندگان
چکیده
Microorganisms may persist in the root canal system after therapy (RCT). The purpose of this study was to explore metronidazole (MTR)- and chlorhexidine (CHX)-loaded hydrogels as potential application intracanal medicaments for disinfection. Ultraviolet cross-linked (gGels) were synthesized by GelMA solution photoinitiator, which loaded with MTR (MTR@gGels) CHX (CHX@gGels). gGels, MTR@gGels CHX@gGels characterized scanning electron microscopy. antimicrobial activity against E. faecalis, S. mutans P. intermedia assessed. Meanwhile, biocompatibility human dental pulp stem cells (hDPSCs) evaluated. DCT, CCK-8, CFU live/dead-stained biofilm results showed that viability significantly reduced vitro. CCK-8 considerable hDPSCs. filling clearance gGels canals demonstrated vivo. Therefore, MTR- CHX-loaded be a
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ژورنال
عنوان ژورنال: Dental Materials Journal
سال: 2021
ISSN: ['0287-4547', '1881-1361']
DOI: https://doi.org/10.4012/dmj.2020-299