Potent Vinblastine C20′ Ureas Displaying Additionally Improved Activity Against a Vinblastine-Resistant Cancer Cell Line
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منابع مشابه
Differential Activity of Vincristine and Vinblastine against Cultured Cells1 ;
Vincristine and vinblastine exhibit differential activity against tumors and normal tissues. In this work, a number of cultured cell lines were assayed for their sensitivity to the antiproliferative and cytotoxic effects of the two drugs following short-term (4 hr) or during continuous exposures. Differential activity was not seen when cells were subjected to continuous exposures. The concentra...
متن کاملDifferential activity of vincristine and vinblastine against cultured cells.
Vincristine and vinblastine exhibit differential activity against tumors and normal tissues. In this work, a number of cultured cell lines were assayed for their sensitivity to the antiproliferative and cytotoxic effects of the two drugs following short-term (4 hr) or during continuous exposures. Differential activity was not seen when cells were subjected to continuous exposures. The concentra...
متن کاملStereocontrolled total synthesis of (+)-vinblastine.
A stereocontrolled total synthesis of (+)-vinblastine was accomplished, featuring preparations of the two indole units by means of a novel indole synthesis via radical cyclization of thioanilide, and a stereoselective coupling of these units.
متن کاملVinblastine-induced Ribosomal Complexes
Vinca alkaloids, vinblastine and vincristine sulfate, have a variety of effects on cells in vivo and in vitro (1-10) . In low sublethal doses, vinblastine and vincristine arrest cells in mitosis (1-3) and prevent the formation and organization of the spindle microtubules (2, 3) . Accumulation of large proteinaceous crystals in platelets (7), in tissue culture cells (8, 10), and in cells of the ...
متن کاملAction of the vinca alkaloids vincristine, vinblastine, and desacetyl vinblastine amide on microtubules in vitro.
The Vinca alkaloids differ in their chemotherapeutic effectiveness and their toxicities. To determine whether differences are due to a differential effect on the assembly of tubulin into microtubules, we examined the effects of vincristine, vinblastine, and a newer alkaloid, desacetyl vinblastine amide, on the assembly of bovine brain tubulin in vitro. The three compounds block bovine tubulin p...
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ژورنال
عنوان ژورنال: ACS Medicinal Chemistry Letters
سال: 2013
ISSN: 1948-5875,1948-5875
DOI: 10.1021/ml400281w