Potensi Antimikroba dan Toksisitas Minyak Atsiri yang Diisolasi dari Biji Jintan (Carum carvi L.)

Caraway (Carum carvi L.) is one of the oldest medicinal plants found in various countries such as West Asia, North Africa, Pakistan, India, America, Northern Europe, Iran, Russia, and Indonesia. This plant has been use for traditional medicines to treat digestive disorders, flatulence, colic infants, headaches, coughs, hypertension, eczema, pneumonia, diabetes, scabies, mouthwash an antiseptic. reported contain around 1-9% essential oil seeds with components potential bioactive compounds. In this study, oils were isolated from caraway determined their chemical content well antimicrobial toxicity. Isolation was carried out by hydrodistillation analysis using Gas Chromatography-Mass Spectrometry (GC-MS) method. The results GC-MS showed presence 35 compounds four main compounds, namely carvone (62.54%), limonene (23.39%), trans-dihydrocarvone (8.20%). activity test disc diffusion method, which strong against Staphylococcus aureus at a concentration ≥75%, fungus Candida albicans. toxicity Brine Shrimp Lethality Test (BSLT) method that seed low toxic Artemia salina Leach shrimp larvae LC50 value 568.3292 mg/L.