POTENCY OF LUTEOLIN WITH SOLID LIPID NANOPARTICLE (SLN)-POLYETHYLENE GLYCOL (PEG) MODIFICATION FOR ARTEMISININ-RESISTANT PLASMODIUM FALCIPARUM INFECTION
نویسندگان
چکیده
منابع مشابه
Laboratory Detection of Artemisinin-Resistant Plasmodium falciparum
Conventional 48-h in vitro susceptibility tests have low sensitivity in identifying artemisinin-resistant Plasmodium falciparum, defined phenotypically by low in vivo parasite clearance rates. We hypothesized originally that this discrepancy was explained by a loss of ring-stage susceptibility and so developed a simple field-adapted 24-h trophozoite maturation inhibition (TMI) assay focusing on...
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Covalent attachment of polyethylene glycol (PEG) to active proteins (PEGylation technology) successfully generated several FDA-approved compounds, including four blockbusters, which are considered non immunogenic. However, PEG antibodies and intolerance to the infusion were reported in some patients with gout treated with pegloticase, a PEG-uricase recently approved by the FDA (Food and Drug Ad...
متن کاملFitness of artemisinin-resistant Plasmodium falciparum in vitro.
OBJECTIVES Drug resistance confers a fitness advantage to parasites exposed to frequent drug pressure, yet these mutations also may incur a fitness cost. We assessed fitness advantages and costs of artemisinin resistance in Plasmodium falciparum in vitro to understand how drug resistance will spread and evolve in a competitive environment. METHODS Genotyping of SNPs, drug susceptibility assay...
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Area and Costa Rica in general, free-ranging dogs are common , including at playgrounds and school yards, sites also vulnerable to nocturnal visits by raccoons. Dogs can have patent B. procyonis parasite infections and can play a role in transmission of the parasite from raccoons to humans. In Costa Rica, cases of larva migrans have been reported. The Unidad de Investigación y Análisis, Regis-t...
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The presented study investigates application of polyethylene glycol (PEG)-coated Fe3O4 nanoparticles as an magnetic nanoadsorbent for magnetic solid-phase extraction (SPE) and the selective removal of toxic heavy metals such as mercury (II) from aqueous solutions and their determination using graphite furnace atomic absorption spectrometry (GF-AAS)...
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ژورنال
عنوان ژورنال: Indonesian Journal of Tropical and Infectious Disease
سال: 2018
ISSN: 2356-0991,2085-1103
DOI: 10.20473/ijtid.v7i3.6726