Potassium channels opener pinacidil have multiple effects on KCl-elicited contractions of isolated non-pregnant rat uterus
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چکیده
منابع مشابه
Effects of calcium channel blocker, mibefradil, and potassium channel opener, pinacidil, on the contractile response of mid-pregnant goat myometrium.
The present study was undertaken to investigate the in vitro influence of mibefradil, a calcium channel blocker, and pinacidil, a potassium channel opener, on pregnant goat myometrial spontaneous rhythmic contractility and contractions induced with the agonist, oxytocin. Longitudinal strips from the distal region of uterus, collected from goats at midgestation, were mounted in an organ bath for...
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* Rad primljen za štampu 30.07.2016. ** Radmila Novaković, Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicine, University of Belgrade, Serbia; Nebojša Radunović, Institute of Gynecology and Obstetrics, Clinical Center of Serbia, Belgrade, Serbia; Jovana Rajković, Vladimir Đokić, Institute of Pharmacology, Clinical Pharmacology and Toxicology, Faculty of Medicin...
متن کاملSpasmolytic Activity of Piper Nigrum Fruit Aqueous Extract on Rat Non-Pregnant Uterus
Black pepper ( Piper nigrum ) from Piperaceae and its main ingredient (piperine) reduces gastric emptying in rats. In Iranian traditional medicine, black pepper is used to relief the menorrhalgia in women. The aim of this study was to investigate the effect of black pepper fruit aqueous extract on non-pregnant rat uterus contractions and the mechanism(s) of its action. To prepare the extract, b...
متن کاملThe effect of resveratrol on contractility of non-pregnant rat uterus: the contribution of K(+) channels.
This study was aimed to evaluate resveratrol (1-100 μM) effect on the spontaneous rhythmic contractions (SRC), oxytocin-induced (0.2 nM, POxC) phasic and tonic (20 nM, TOxC) contractions of isolated rat uterus. The SRC and POxC were more sensitive to resveratrol than TOxC (pD2 values: 4.53 and 4.66 versus 4.06). Different blockers of K(+) channels (glibenclamide, tetraethylamonium, iberiotoxin,...
متن کاملATP-sensitive potassium channels modulate in vitro tocolytic effects of β₂-adrenergic receptor agonists on uterine muscle rings in rats in early but not in late pregnancy.
AIM To investigate whether ATP-sensitive potassium (K(ATP)) channels modulate the tocolytic effect of β2-adrenergic receptor (β2-AR) agonists (ritodrine and salmeterol) in early-pregnant (day 6) and late-pregnant (day 22) rat uterus in vitro, in order to examine the relation between the K(ATP) channel sulphonylurea-binding regulatory subunit (SUR) expression and pharmacological reactivity of β2...
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ژورنال
عنوان ژورنال: Acta veterinaria
سال: 2011
ISSN: 0567-8315
DOI: 10.2298/avb1103133n