منابع مشابه
Potassium Channels in Myelinated Nerve
The permeability of K channels to various cations is studied in myelinated nerve. Ionic currents under voltage clamp are measured in Ringer solution containing tetrodotoxin and a high concentration of the test ion. Reversal potentials for current in K channels are determined and used with the Goldman-Hodgkin-Katz equation to calculate relative permeabilities. The ratios P(Tl):P(K):P(Rb):P(NHNH4...
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The permeability of K channels to various cations is studied in myelinated nerve. Ionic currents under voltage clamp are measured in Ringer solution containing tetrodotoxin and a high concentration of the test ion. Reversal potentials for current in K channels are determined and used with the Goldman-Hodgkin-Katz equation to calculate relative permeabilities. The ratios PTI:PK:PRb:PNH4 are 2.3:...
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A 7-year-old girl of second degree consanguineous parents, presented with an 8 months history of intermittent exotropia of the left eye. Cycloplegic refraction was -0.25.-0.50×165o and -3.00.0.50×20o in the right and left eyes respectively. An initial objective assessment of the visual function showed a best corrected visual acuity of 12/10 in the right eye and 6/10 in the left eye. Fundoscopy ...
متن کاملEffects of some potassium channel blockers on the ionic currents in myelinated nerve.
The effects of some potassium channel blockers on the ionic currents and on the so-called K(+)-depolarization in intact myelinated nerve fibres were studied. 4-AP, and in particular, Flaxedil, proved to be selective K(+)-current blockers. However, TEA, a crown ether (DCH18C6), a longchained triethylammonium compound (C10-TriEA), capsaicin, and the extract from the medicinal herb Ruta graveolens...
متن کاملLocal anesthetics potently block a potential insensitive potassium channel in myelinated nerve
Effects of some local anesthetics were studied in patch clamp experiments on enzymatically demyelinated peripheral amphibian nerve fibers. Micromolar concentrations of external bupivacaine depolarized the excised membrane considerably. The flicker K+ channel was found to be the most sensitive ion channel to local anesthetics in this preparation. Half-maximum inhibiting concentrations (IC50) for...
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ژورنال
عنوان ژورنال: Journal of General Physiology
سال: 1973
ISSN: 1540-7748,0022-1295
DOI: 10.1085/jgp.61.6.669