منابع مشابه
Systematic Functional Prioritization of Protein Posttranslational Modifications
Protein function is often regulated by posttranslational modifications (PTMs), and recent advances in mass spectrometry have resulted in an exponential increase in PTM identification. However, the functional significance of the vast majority of these modifications remains unknown. To address this problem, we compiled nearly 200,000 phosphorylation, acetylation, and ubiquitination sites from 11 ...
متن کاملProtein Synthesis: Translation and Posttranslational Modifications
Messenger RNA Is the Carrier of Information Present in DNA 00 Ribosomes Are Workbenches for Protein Biosynthesis 00 Transfer RNA Acts as a Bilingual Translator Molecule 00 The Genetic Code Uses a Four-Letter Alphabet of Nucleotides 00 Codons in mRNA Are Three-Letter Words 00 Punctuation 00 Codon–Anticodon Interactions Permit Reading of mRNA 00 ‘‘Breaking’’ the Genetic Code 00 Mutations 00 Amino...
متن کاملSnapShot: p53 Posttranslational Modifications
P ho sp ho ry la ti o n N-Terminal: S6, S9, S15, T18, S20 ATM, DNAPK, • CK1 ERKs, ATR, p38 • kinase, mTOR, Chk1/Chk2, JNK, MAPKAP2, Hipk4 Activated by DNA damage, UV light, ionizing radiation, replicative senes• cence, or phosphatidylcholines. N-terminal phosphorylation causes p53 stabilization by inhibiting the p53• MDM2 interaction. Knockin mice carrying separate analogs to human Ser18/ • Ser...
متن کاملPosttranslational Modifications of Myosin Light Chains Determine the Protein Fate
The advances in proteomics over the last decade have made it possible for a more detailed study of protein posttranslational modifications. Posttranslational modification of proteins is an important signaling mechanism regulating vital pathways ranging from transcription to translation, in metabolism, cell survival, and cell death. Posttranslational modification of proteins has commonly been as...
متن کاملPosttranslational modifications of tissue factor.
Tissue factor (TF), a membrane protein, is an initiator of blood coagulation in vivo. In this review we discuss how posttranslational modifications affect activity and other properties of TF. Glycosylation of the extracellular domain and the composition of carbohydrates at three glycosylation sites have an influence on TF activity in the extrinsic FXase by increasing the rate of FX proteolysis....
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ژورنال
عنوان ژورنال: Molecular & Cellular Proteomics
سال: 2006
ISSN: 1535-9476
DOI: 10.1074/mcp.r600009-mcp200