Postsynaptic nigrostriatal dopamine receptors and their role in movement regulation

Physiological and Pharmacopathological Role of Dopamine Receptors and Brain Dopamine Systems

This article has no abstract

Ionotropic Glutamate Receptors and their Role in Neurological Diseases

Glutamate is extensively and relatively uniformly distributed in the central nervous system (CNS) and its effects mediated by two distinct groups of receptors including Ionotropic and metabotropic glutamate receptors. Concentration of glutamate in the nervous system is much higher than in other tissues. Glutamate receptors play an important role in synaptic transmission, neural plasticity and n...

Negative feedback regulation of nigrostriatal dopamine release: mediation by striatal D1 receptors.

The nigrostriatal dopamine system of the mammalian brain is necessary for normal voluntary motor activity. Dopamine exerts its effects by acting on two primary receptor subtypes: D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptors. Previous research has indicated that both subtypes are involved in the negative feedback regulation of dopamine release in the brain. However, the role of D1-...

Dopamine auto- and postsynaptic receptors: possible interference by gallamine.

Maturational Regulation of Glutamate Receptors and Their Role in Neuroplasticity

Glutamate receptors mediate most excitatory synaptic transmission in the brain. Additionally, they mediate many forms of synaptic plasticity such as those thought to comprise the physiological basis of learning and memory. In the developing brain, glutamate receptor activation is required for appropriate synaptogenesis and activity-driven refinement of functional synaptic networks (1,2). Thus, ...