Postnatal human enteric neuronal progenitors can migrate, differentiate, and proliferate in embryonic and postnatal aganglionic gut environments
نویسندگان
چکیده
منابع مشابه
14-P002 Mesoderm derived from mouse embryonic stem cells displays nephrogenic potential
The enteric nervous system (ENS) derives from neural crest, which invade and migrate along the developing gut, proliferate extensively, and differentiate into neurons and glial cells organized as interconnected ganglia that control complex behaviours of the gut, such as peristalsis. While most ENS progenitors undergo differentiation, cells exhibiting properties of enteric progenitor cells (EPCs...
متن کامل14-P003 Identification of genes expressed in the anterior definitive endoderm
The enteric nervous system (ENS) derives from neural crest, which invade and migrate along the developing gut, proliferate extensively, and differentiate into neurons and glial cells organized as interconnected ganglia that control complex behaviours of the gut, such as peristalsis. While most ENS progenitors undergo differentiation, cells exhibiting properties of enteric progenitor cells (EPCs...
متن کاملPostnatal mouse subventricular zone neuronal precursors can migrate and differentiate within multiple levels of the developing neuraxis.
The mammalian subventricular zone (SVZ) of the lateral wall of the forebrain ventricle retains a population of proliferating neuronal precursors throughout life. Neuronal precursors born in the postnatal and adult SVZ migrate to the olfactory bulb where they differentiate into interneurons. Here we tested the potential of mouse postnatal SVZ precursors in the environment of the embryonic brain:...
متن کامل14-P001 SOX2 expression provides a means to identify and isolate ENS progenitors
The enteric nervous system (ENS) derives from neural crest, which invade and migrate along the developing gut, proliferate extensively, and differentiate into neurons and glial cells organized as interconnected ganglia that control complex behaviours of the gut, such as peristalsis. While most ENS progenitors undergo differentiation, cells exhibiting properties of enteric progenitor cells (EPCs...
متن کاملTransplanted progenitors generate functional enteric neurons in the postnatal colon.
Cell therapy has the potential to treat gastrointestinal motility disorders caused by diseases of the enteric nervous system. Many studies have demonstrated that various stem/progenitor cells can give rise to functional neurons in the embryonic gut; however, it is not yet known whether transplanted neural progenitor cells can migrate, proliferate, and generate functional neurons in the postnata...
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ژورنال
عنوان ژورنال: Pediatric Research
سال: 2017
ISSN: 0031-3998,1530-0447
DOI: 10.1038/pr.2017.4