Postmenopausal Status Exacerbates Stress-Related Neurological Disorders in Rats

Aims: This study was aimed at assessing the effects of social instability stress (SIS) and immobilization (IS) in postmenopausal (PM) conditions. Postmenopause is a physiological state often associated with mild neuronal disorders (NDs) such as anxiety irritability. The aging worldwide population, coupled multiple stressors, can lead to significant public health concerns, including severe NDs.
 Place Duration Study: Tests analyses were carried out within confines Laboratory Animal Physiology University Yaoundé I (Cameroon) for 3 months. 
 Study Design: To induce PM syndrome, an 84-day ovariectomized Wistar rat model used.
 Methodology: Random sampling 4 groups 6 rats, each aged between 8 10 weeks, used. SIS IS induced during installation. Behavioral status, biochemical, histopathological out.
 Results: combined exacerbates NDs by low estrogen levels. Furthermore, stressed rats are more depressed anxious than control. They presented hippocampal inflammation, oxidative stress, memory impairment owing levels ACh reduced expression hippocampus. Overall, status makes linked worse rats.
 Conclusion: Stress promotes neuroinflammation, death, leading greater affective cognition when low. Thus, there need focus on management menopausal life.