Post-translational modification of pregnane x receptor
نویسندگان
چکیده
منابع مشابه
Allosteric post-translational modification codes.
Post-translational modifications (PTMs) have been recognized to impact protein function in two ways: (i) orthosterically, via direct recognition by protein domains or through interference with binding; and (ii) allosterically, via conformational changes induced at the functional sites. Because different chemical types of PTMs elicit different structural alterations, the effects of combinatorial...
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Post-translational modifications (PTMs) are chemical alterations to a protein following translation, regulating stability and function. Reversible phosphorylation is an example of an important and well studied PTM involved in a number of cellular processes. SUMOylation is another PTM known to modify a large number of proteins and plays a role in various cellular processes including: cell cycle ...
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A new global post-translational modification (PTM) discovery strategy, G-PTM-D, is described. A proteomics database containing UniProt-curated PTM information is supplemented with potential new modification types and sites discovered from a first-round search of mass spectrometry data with ultrawide precursor mass tolerance. A second-round search employing the supplemented database conducted wi...
متن کاملActivation of pregnane X receptor inhibits
Received 8 August 2012 Revised 7 November 2012 Accepted 2 December 2012 Published Online First 5 January 2013 ABSTRACT Objective To assess the antifibrotic effects of pregnane X receptors (PXRs) in experimental dermal fibrosis. Methods The antifibrotic effects of PXR activation by 5-pregnen-3β-ol-20-one-16α-carbonitrile (PCN) were studied in the bleomycin model for prevention of dermal fibrosis...
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Post-translational modifications of proteins control many biological processes. This is also an important process in the pathogenesis of diabetes mellitus. Adiponectin is an insulin-sensitizing adipokine with antidiabetic, anti-atherogenic, anti-inflammatory and cardioprotective properties. The role of posttranslational modifications in regulating the biosynthesis of high molecular weight adipo...
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ژورنال
عنوان ژورنال: Pharmacological Research
سال: 2011
ISSN: 1043-6618
DOI: 10.1016/j.phrs.2011.02.011