Post-Translational Modification of Drp1 is a Promising Target for Treating Cardiovascular Diseases

Mitochondria are essential for cell growth, fission, differentiation, and survival, particularly in undivided cells with high energy requirements, such as cardiomyocytes. The morphology position of mitochondria change the activity mitochondrial fission proteins fusion proteins. These regulatory mechanisms substantially affect cardiomyocyte supply normal function. In dynamin-related protein 1 (Drp1) is involved separation degradation damaged mitochondria, accurately regulates renewal number. Recent studies have revealed a variety post-translational modification (PTMs) Drp1, including phosphorylation, SUMOylation, acetylation, O-GlcNAcylation, S-sulfhydration. modifications ensure that Drp1 continues to function normally various signaling pathways, by modulating its activity, stability, subcellular localization. This article provides an overview relationship between PTMs cardiovascular diseases heart failure, myocardial infarction, ischemia-reperfusion, describes how these can be targeted regulated, help guide disease treatment.