Post-transcriptional regulation of tumour necrosis factor alpha production

Post-transcriptional regulation of tumour necrosis factor alpha production.

Tumour necrosis factor á (TNFá) is a proinflammatory cytokine produced by activated macrophages, lymphocytes and other cells. The production of TNFá is under transcriptional and post-transcriptional control. Post-transcriptional control of TNFá expression is achieved by regulating translational initiation, mRNA stability, and polyadenylation. 7 10 An adenine and uridine (AU)-rich element (ARE) ...

Epigenetic regulation of tumor necrosis factor alpha.

Tumor necrosis factor alpha (TNF-alpha) is a potent cytokine which regulates inflammation via the induction of adhesion molecules and chemokine expression. Its expression is known to be regulated in a complex manner with transcription, message turnover, message splicing, translation, and protein cleavage from the cell surface all being independently regulated. This study examined both cell line...

Tumour necrosis factor alpha blockade and the risk of vasculitis.

Treatment of hidradenitis suppurativa with tumour necrosis factor-alpha inhibitors.

Hidradenitis suppurativa (HS) is a common inflammatory skin disease. Medical treatment is often disappointing and in severe disease surgery remains the therapy of choice. Extensive surgery may be effective but also mutilating. Patients experience a significant reduction in quality of life and the need for new treatment modalities are urgent. In recent years patients with HS have been treated of...

Red cell ABO incompatibility and production of tumour necrosis factor-alpha.

Tumour necrosis factor-alpha (TNF) is a major mediator of diverse pathophysiological events similar to those of haemolytic transfusion reactions (HTR), such as fever, intravascular coagulation and organ failure. However, the possible role of TNF in HTR has not been investigated. We have constructed an in vitro whole blood model of HTR to examine whether TNF may be produced in red cell ABO incom...