Possible Nutrition-Related Mechanisms of Metabolic Management in Cancer Treatment

Context: Somatic mutation theory has been considered as a potential cause for cancer. However, major inconsistencies with the gene have necessitated serious reconsideration of this assumption. According to these inconsistencies, cancer may be metabolic disorder. mitochondrial theory, substrate-level phosphorylation suggested superior oxidative in cells. Cancer therapies such ketogenic diets (KD) and limitation glutamine calorie can beneficial are line theory. In study, we reviewed effects KD well restriction various types/stages focus on possible mechanisms. Evidence Acquisition: A comprehensive electronic search different databases was performed using “cancer”, “ketogenic diet”, “metabolic” main keywords. Results: Emerging evidence indicated that affect tumor cells by reducing glucose availability simultaneous elevation ketone bodies non-fermentable fuels. more effective non-toxic therapeutic measure combination targeting agents, chloroquine lysosomal targeting, hyperbaric oxygen therapy, restriction. Conclusions: This approach promising strategy management.