Possible mutagenic properties and carcinogenic action of the irritant gaseous pollutants NO2, O3, and SO2.

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منابع مشابه

Possible mutagenic properties and carcinogenic action of the irritant gaseous pollutants NO2, O3, and SO2.

Carcinogenic or cocarcinogenic effects of NO2, O3, and SO2 have not been proven to date with sufficient reliability. However, nitrosamine formation after exposure to NO2- or O3-induced decrease in benzpyrene hydroxylase are potential hazards. A final revaluation of a possible cocarcinogenic action of SO2 requires further experimental studies.

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Knowing the mutagenic and carcinogenic properties of chemicals is very important for their hazard (and risk) assessment. One of the crucial events that trigger genotoxic and sometimes carcinogenic effects is the forming of adducts between chemical compounds and nucleic acids and histones. This review takes a look at the mechanisms related to specific functional groups (structural alerts or toxi...

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ژورنال

عنوان ژورنال: Environmental Health Perspectives

سال: 1978

ISSN: 0091-6765,1552-9924

DOI: 10.1289/ehp.782291