Possible environmental determinants of juvenile idiopathic arthritis

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Review Possible environmental determinants of juvenile idiopathic arthritis

Like other autoimmune diseases, including adult RA, risk of developing juvenile idiopathic arthritis (JIA) is thought to be determined by a complex combination of genetic and environmental factors. Although some predisposing JIA genes are now being identified, research aimed at identifying environmental influences lags behind most other autoimmune conditions. Here we review research to date, fr...

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Background Multicentric carpotarsal osteolysis (MCTO), a skeletal dysplasia presents in early childhood mimicking juvenile idiopathic arthritis (JIA). Recognition of this syndrome is essential to avoid unnecessary treatment with immunosuppressive agents because of different course and treatment. Case Report A 3-year-old boy presented with swelling and restriction of right wrist joint and left ...

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Juvenile idiopathic arthritis (JIAs) is the most common chronic rheumatic disease of childhood and is an important cause of disability. The folic acid analog methotrexate is the first choice disease-modifying anti-rheumatic drug in this disease, however, 35-45% of patients fail to respond. Molecular elements, such as variants in genes of pharmacological relevance, influencing response to methot...

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Background JIA means arthritis of unknown origin, lasting more than 6 weeks and that arise before 16 years of age. It is characterized by pain, swelling, stiffness and functional limitation of joints. The Multidimensional Self-Concept Scale assesses global self-concept and six context-dependent self-concept domains that are functionally and theoretically important in the social-emotional adjust...

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Juvenile idiopathic arthritis.

Juvenile idiopathic arthritis (JIA), a term referring to a group of disorders characterized by chronic arthritis, is the most common chronic rheumatic illness in children and is a significant cause of short- and long-term disability. This article discusses the classification, differential diagnosis, and treatment of JIA.

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ژورنال

عنوان ژورنال: Rheumatology

سال: 2009

ISSN: 1462-0324,1462-0332

DOI: 10.1093/rheumatology/kep383