Possibilities and prospects for antioxidant therapy in ocular diseases

The eye is particularly vulnerable to oxidative stress due its constant exposure atmospheric oxygen, sunlight, ultraviolet and ionizing radiation, chemicals, pollutants, microorganisms that may shift the physiological balance towards oxidation. Today, considered a major pathogenetic feature of wide spectrum ocular conditions including diseases lens (cataract), anterior chamber (glaucoma), cornea (keratoconus, traumatic injuries, post-operative conditions), surface (pterygium, dry syndrome), retina (uveitis, retinopathies), optic nerve (optic neuropathies, glaucoma). Potential strategies for therapy in conditions, associated with stress, include direct inhibition lipid peroxidation, induction Nrf2 transcription factor signaling, repression sequestration vascular endothelial growth (VEGF), use agents antioxidant effect. Methylethylpyridinol or 3-oxy-6-methyl-2-ethylpyridine hydrochloride, potent free radical scavenger, often regarded as agent ophthalmological purposes. characterized by possibility being used different types dosage forms. In ophthalmology, it given injection, well instillation form drops. can be treatment prevention inflammation burn injuries cornea, hemorrhages into sclera, thrombosis central retinal vein branches, diabetic retinopathy complications myopia, protection when exposed high intensity light wearing contact lenses. This paper reviews main features leading diseases, possibilities using methylethylpyridinol.