Positive Spikes with Neuronal Migration Disorders
نویسندگان
چکیده
منابع مشابه
Disorders of neuronal migration.
Neuronal migration constitutes one of the major processes by which the central nervous system takes shape. Detailed knowledge about this important process now exists for different brain regions in rodent and monkey models as well as in the human. In the human, distinct genetic, chromosomal and environmental causes are known that affect neuronal migration, often in a morphologically distinct pat...
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Spikes of single cortical neurons can exert powerful effects even though most cortical synapses are too weak to fire postsynaptic neurons. A recent study combining single-cell stimulation with population imaging has visualized in vivo postsynaptic firing in genetically identified target cells. The results confirm predictions from in vitro work and might help to understand how the brain reads si...
متن کاملIncreased seizure susceptibility in adult rats with neuronal migration disorders.
Recent data show that neuronal migration disorders (NMD) lower the seizure threshold in the immature brain. To assess if this is an age-related phenomenon, kainic acid (KA) was administered to induce status epilepticus in adult rats with NMD. Results of the present study demonstrate that adult rats with NMD had a shorter latency to seizures and longer duration of status epilepticus compared to ...
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We propose two control strategies for achieving desired firing patterns in a physiologically realistic model neuron. The techniques are powerful, efficient, and robust, and we have applied them successfully to obtain a range of targeted spiking behaviors. The methods complement each other: one involves the manipulation of only a parameter, the applied soma current, and the other involves the ma...
متن کاملEvidence of enhanced kindling and hippocampal neuronal injury in immature rats with neuronal migration disorders.
PURPOSE Neuronal migration disorders (NMD) are often found in patients with epilepsy. However, the mechanisms linking these two pathologies are not yet fully understood. In this study, we evaluated whether NMD increased kindling seizure susceptibility and seizure-induced acute neuronal damage in the immature brain. METHODS Experimental NMD were produced by exposing pregnant rats (gestation da...
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ژورنال
عنوان ژورنال: Pediatric Neurology Briefs
سال: 1997
ISSN: 2166-6482,1043-3155
DOI: 10.15844/pedneurbriefs-11-2-3