Positive selection of co-opted mobile genetic elements in a mammalian gene
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چکیده
منابع مشابه
Positive selection of co-opted mobile genetic elements in a mammalian gene
The proopiomelanocortin (Pomc) gene encodes a prepropeptide with essential functions in the response to stress and energy balance, which is expressed in the pituitary and hypothalamus of vertebrate animals. Neuronal expression of Pomc is controlled by two distal enhancers named nPE1 and nPE2. Using transgenic mice, we observed that both enhancers drive identical expression patterns in the mamma...
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Michel J. Weber doi:10.1371/journal.pgen.0020205 In PLoS Genetics, volume 2, issue 12: In the Materials and Methods, the URL to the Yass online program was incorrectly listed. The correct URL is http:// bioinfo.lifl.fr/yass/yass.php. This correction note may be found online at doi:10.1371/journal.pgen.0030036 Published February 23, 2007 Citation: (2007) Correction: Mammalian small nucleolar RNA...
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Acquisition of cis-regulatory elements is a major driving force of evolution, and there are several examples of developmental enhancers derived from transposable elements (TEs). However, it remains unclear whether one enhancer element could have been produced via cooperation among multiple, yet distinct, TEs during evolution. Here we show that an evolutionarily conserved genomic region named AS...
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The neocortex is a mammalian-specific structure that is responsible for higher functions such as cognition, emotion and perception. To gain insight into its evolution and the gene regulatory codes that pattern it, we studied the overlap of its active developmental enhancers with transposable element (TE) families and compared this overlap to uniformly shuffled enhancers. Here we show a striking...
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ژورنال
عنوان ژورنال: Mobile Genetic Elements
سال: 2012
ISSN: 2159-256X
DOI: 10.4161/mge.20267