Positive selection drives a correlation between non-synonymous/synonymous divergence and functional divergence
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چکیده
منابع مشابه
Positive selection drives a correlation between non-synonymous/synonymous divergence and functional divergence
MOTIVATION Functional divergence among proteins is often assumed to be strongly influenced by natural selection, as inferred from the ratio of non-synonymous nucleotide divergence (d(N)) to synonymous nucleotide divergence (d(S)). That is, the more a mutation changes protein function, the more likely it is to be either selected against or selectively favored, and because the d(N)/d(S) ratio is ...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2008
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btn205