Position Matters: Network Centrality Considerably Impacts Rates of Protein Evolution in the Human Protein–Protein Interaction Network
نویسندگان
چکیده
منابع مشابه
Position Matters: Network Centrality Considerably Impacts Rates of Protein Evolution in the Human Protein–Protein Interaction Network
The proteins of any organism evolve at disparate rates. A long list of factors affecting rates of protein evolution have been identified. However, the relative importance of each factor in determining rates of protein evolution remains unresolved. The prevailing view is that evolutionary rates are dominantly determined by gene expression, and that other factors such as network centrality have o...
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Network evolution based on centrality.
We study the evolution of networks when the creation and decay of links are based on the position of nodes in the network measured by their centrality. We show that the same network dynamics arise under various centrality measures, and solve analytically the network evolution. During the complete evolution, the network is characterized by nestedness: the neighborhood of a node is contained in t...
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ژورنال
عنوان ژورنال: Genome Biology and Evolution
سال: 2017
ISSN: 1759-6653
DOI: 10.1093/gbe/evx117