POS0163 INCIDENT FRACTURE RISK PREDICTION USING THE FRAGILITY SCORE CALCULATED BY LUMBAR SPINE RADIOFREQUENCY ECHOGRAPHIC MULTI SPECTROMETRY (REMS) SCANS

Background: The main consequence of osteoporosis is the occurrence fractures due to bone fragility, with important sequelae in terms disability and mortality. It has been already demonstrated that information about mass density (BMD) alone not sufficient predict risk fragility fractures, since several occur patients normal BMD [1]. Fragility Score a parameter allows estimate skeletal thanks trans-abdominal ultrasound scan performed Radiofrequency Echographic Multi Spectrometry (REMS) technology. calculated by comparing results spectral analysis patient’s raw signals reference models representative fragile non-fragile bones [2]. dimensionless parameter, which can vary from 0 100, proportion degree independently BMD. Objectives: This study aims evaluate effectiveness Score, measured during densitometry exam REMS technology at lumbar spine, identifying incident osteoporotic follow-up period 5 years. Methods: Caucasian women age between 30 90 were scanned spinal DXA. incidence was assessed ability discriminate without subsequently evaluated compared discriminatory T-score DXA REMS. Results: Overall, 533 (median age: 60 years; interquartile range [IQR]: 54-66 years) completed 42 months; IQR: 35-56 months), 73 had sustained an fracture. Both median values significantly lower fractured than for non-fractured ones, conversely, higher (Table 1). Table 1. Analysis Median ranges (IQR) are reported. p-value derived Mann-Whitney test. Patients fracture [median (IQR)] -1.9 (-2.7 -1.0) -2.6 (-3.3 -1.7) 0.0001 -2.0 (-2.8 -1.1) -2.7 (-3.5 -1.9) <0.0001 29.9 (25.7 36.2) 53.0 (34.2 62.5) By evaluating capability with/without obtained value ROC area under curve (AUC) 0.80, AUC (0.66) (0.64), difference statistically significant (Figure Figure comparison classification fractures. Furthermore, correlation low, Pearson coefficient r =-0.19 -0.18 T-score. Conclusion: found be effective tool prediction population women, performances superior those values. Therefore, this presents high potential as diagnostic early identification subsequent treatment fragility. References: [1]Diez Perez A et al. Aging Clin Exp Res 2019; 31(10):1375-1389. [2]Pisani P Measurement 2017; 101:243–249. Disclosure Interests: None declared