Population-based structural variation discovery with Hydra-Multi
نویسندگان
چکیده
منابع مشابه
Genome analysis Population-based structural variation discovery with Hydra-Multi
Summary: Current strategies for SNP and INDEL discovery incorporate sequence alignments from multiple individuals to maximize sensitivity and specificity. It is widely accepted that this approach also improves structural variant (SV) detection. However, multisample SV analysis has been stymied by the fundamental difficulties of SV calling, e.g. library insert size variability, SV alignment sign...
متن کاملPopulation-based structural variation discovery with Hydra-Multi
UNLABELLED Current strategies for SNP and INDEL discovery incorporate sequence alignments from multiple individuals to maximize sensitivity and specificity. It is widely accepted that this approach also improves structural variant (SV) detection. However, multisample SV analysis has been stymied by the fundamental difficulties of SV calling, e.g. library insert size variability, SV alignment si...
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Denial constraints (DCs) are a generalization of many other integrity constraints (ICs) widely used in databases, such as key constraints, functional dependencies, or order dependencies. Therefore, they can serve as a unified reasoning framework for all of these ICs and express business rules that cannot be expressed by the more restrictive IC types. The process of formulating DCs by hand is di...
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ژورنال
عنوان ژورنال: Bioinformatics
سال: 2014
ISSN: 1460-2059,1367-4803
DOI: 10.1093/bioinformatics/btu771