Pooled Analysis and Meta-analysis of Glutathione S-Transferase M1 and Bladder Cancer: A HuGE Review
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منابع مشابه
Pooled analysis and meta-analysis of glutathione S-transferase M1 and bladder cancer: a HuGE review.
Smoking is a known risk factor for bladder cancer. The product of the GSTM1 gene, glutathione S-transferase M1 (GSTM1), is involved in the detoxification of polycyclic aromatic hydrocarbons found in tobacco smoke; a homozygous deletion of this gene in approximately 50% of Caucasians and Asians results in a lack of GSTM1 enzyme activity. Most studies examining the relation between bladder cancer...
متن کاملHuman Genome Epidemiology (HuGE) Review Pooled Analysis and Meta-analysis of the Glutathione S-Transferase P1 Ile 105Val Polymorphism and Bladder Cancer: A HuGE-GSEC Review
1 Department of General Practice, Katholieke Universiteit Leuven, Comprehensive Cancer Institute Limburg, Limburg, Belgium. 2 Unit of Genetic Epidemiology, Department of Public Health and Epidemiology, University of Birmingham, Birmingham, United Kingdom. 3 Department of Occupational and Environmental Medicine andPsychiatricEpidemiology, LundUniversity, Lund,Sweden. 4 Institute for Occupational...
متن کاملGlutathione S-transferase M1 polymorphism and bladder cancer risk: a meta-analysis involving 33 studies.
Glutathione S-transferase M1 (GSTM1) might be involved in inactivation of procarcinogens that contribute to the genesis and progression of cancers. GSTM1 null status has been extensively studied as a risk factor in bladder cancer susceptibility. The aim of this study is to evaluate the role of GSTM1 null genotype in bladder cancer risk. All available studies were considered in this meta-analysi...
متن کاملPooled analysis and meta-analysis of the glutathione S-transferase P1 Ile 105Val polymorphism and bladder cancer: a HuGE-GSEC review.
The glutathione S-transferase P1 genotype (GSTP1) is involved in the inactivation of cigarette smoke carcinogens, and sequence variation in the gene may alter bladder cancer susceptibility. To examine the association between GSTP1Ile 105Val and bladder cancer, the authors undertook a meta- and pooled analysis. Summary crude and adjusted odds ratios and corresponding 95% confidence intervals wer...
متن کاملHuman Genome Epidemiology (HuGE) Review Glutathione S-Transferase M1 (GSTM1) Polymorphisms and Lung Cancer: A Literature-based Systematic HuGE Review and Meta-Analysis
1 Department of Medicine, Faculty of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. 2 School of Environmental Health, University of British Columbia, Vancouver, British Columbia, Canada. 3 United Kingdom HuGENet Coordinating Centre, Strangeways Research Laboratory, University of Cambridge, Cambridge, United Kingdom. 4 MRC Biostatistics Unit, Institute of Public H...
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ژورنال
عنوان ژورنال: American Journal of Epidemiology
سال: 2002
ISSN: 0002-9262
DOI: 10.1093/aje/kwf018