Polyvalent vaccine approaches to combat HIV-1 diversity
نویسندگان
چکیده
منابع مشابه
Polyvalent vaccine approaches to combat HIV‐1 diversity
A key unresolved challenge for developing an effective HIV-1 vaccine is the discovery of strategies to elicit immune responses that are able to cross-protect against a significant fraction of the diverse viruses that are circulating worldwide. Here, we summarize some of the immunological implications of HIV-1 diversity, and outline the rationale behind several polyvalent vaccine design strategi...
متن کاملDiversity considerations in HIV-1 vaccine selection.
Globally, human immunodeficiency virus-type 1 (HIV-1) is extraordinarily variable, and this diversity poses a major obstacle to AIDS vaccine development. Currently, candidate vaccines are derived from isolates, with the hope that they will be sufficiently cross-reactive to protect against circulating viruses. This may be overly optimistic, however, given that HIV-1 envelope proteins can differ ...
متن کاملBrian Gaschen , Diversity Considerations in HIV - 1 Vaccine Selection
http://www.sciencemag.org/cgi/content/full/296/5577/2354 version of this article at: including high-resolution figures, can be found in the online Updated information and services, http://www.sciencemag.org/cgi/content/full/296/5577/2354/DC1 can be found at: Supporting Online Material found at: can be related to this article A list of selected additional articles on the Science Web sites http:/...
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ژورنال
عنوان ژورنال: Immunological Reviews
سال: 2017
ISSN: 0105-2896
DOI: 10.1111/imr.12516