Polyunsaturated fatty acid elongation and desaturation in activated human T-cells: ELOVL5 is the key elongase
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چکیده
منابع مشابه
Fatty acid desaturation and chain elongation in eukaryotes
Although the contribution of lipid molecules to the hydrophobic character of membranes was recognized late in the nineteenth century, the nutritional importance of specific lipid molecules was first revealed through the pioneering work of Burr and Burr in 1929. They fed rats a fat-free diet and observed that retarded growth, scaly skin, tail necrosis and eventual death were reversed by feeding ...
متن کاملPolyunsaturated fatty acid-specific elongation enzymes.
We have isolated a novel gene (GLELO) from Mortierella alpina and its homologue (CEELO1) from Caenorhabditis elegans and demonstrate the involvement of their encoded proteins in the elongation of C(18) polyunsaturated fatty acids.
متن کاملFatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice.
Nonalcoholic fatty liver disease is a major public health concern in the obese and type 2 diabetic populations. The high-fat lard diet induces obesity and fatty liver in C57BL/6J mice and suppresses expression of the PPAR-target gene, FA elongase 5 (Elovl5). Elovl5 plays a key role in MUFA and PUFA synthesis. Increasing hepatic Elovl5 activity in obese mice lowered hepatic TGs and endoplasmic r...
متن کاملGene Expression of Desaturase (FADS1 and FADS2) and Elongase (ELOVL5) Enzymes in Peripheral Blood: Association with Polyunsaturated Fatty Acid Levels and Atopic Eczema in 4-Year-Old Children
BACKGROUND It is unknown if changes in the gene expression of the desaturase and elongase enzymes are associated with abnormal n-6 long chain polyunsaturated fatty acid (LC-PUFA) levels in children with atopic eczema (AE). We analyzed whether mRNA-expression of genes encoding key enzymes of LC-PUFA synthesis (FADS1, FADS2 and ELOVL5) is associated with circulating LC-PUFA levels and risk of AE ...
متن کاملEstrogen Enhances the Expression of the Polyunsaturated Fatty Acid Elongase Elovl2 via ERα in Breast Cancer Cells
Endocrine therapy is the first-line targeted adjuvant therapy for hormone-sensitive breast cancer. In view of the potential anticancer property of the omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) together with chemotherapy in estrogen receptor alpha (ERα) positive mammary tumors, we have explored the regulation by estradiol of the fatty acid desaturation and elongation enzymes ...
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ژورنال
عنوان ژورنال: Journal of Lipid Research
سال: 2018
ISSN: 0022-2275
DOI: 10.1194/jlr.m090050